Invention Grant
- Patent Title: Process for producing muscarine receptor antagonist and intermediate therefor
- Patent Title (中): 生产毒蕈碱受体拮抗剂及其中间体的方法
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Application No.: US11721378Application Date: 2005-12-13
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Publication No.: US07868183B2Publication Date: 2011-01-11
- Inventor: Yuuji Ishiguro , Yasuhiro Aizawa , Masahiro Aono
- Applicant: Yuuji Ishiguro , Yasuhiro Aizawa , Masahiro Aono
- Applicant Address: JP Tokyo
- Assignee: Kyorin Pharmaceutical Co., Ltd.
- Current Assignee: Kyorin Pharmaceutical Co., Ltd.
- Current Assignee Address: JP Tokyo
- Agency: Oblon, Spivak, McClelland, Maier & Neustadt, L.L.P.
- Priority: JP2004-361243 20041214
- International Application: PCT/JP2005/023216 WO 20051213
- International Announcement: WO2006/064945 WO 20060622
- Main IPC: C07D233/64
- IPC: C07D233/64

Abstract:
The industrial production of 4-(2-methyl-1-imidazolyl)-2,2-diphenylbutanamide, a urinary incontinence remedy, necessitates elimination of problems concerning the use of a synthetic adsorbent, e.g., HP-20, the efficiency of operation with the same, purification efficiency, etc. An acid salt, e.g., hydrochloride or phosphate, of 4-(2-methyl-1-imidazolyl)-2,2-diphenylbutanamide or a hydrate of any of these salts is used as an intermediate. This intermediate is neutralized and then purified. Thus, high-purity 4-(2-methyl-1-imidazolyl)-2,2-diphenylbutanamide is easily obtained in satisfactory yield. The industrial-scale production process has been thus established.
Public/Granted literature
- US20090299075A1 PROCESS FOR PRODUCING MUSCARINE RECEPTOR ANTAGONIST AND INTERMEDIATE THEREFOR Public/Granted day:2009-12-03
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