A programmable gain circuit suitable for a programmable gain amplifier is described. In one design, the programmable gain circuit includes multiple attenuation circuits coupled in series. Each attenuation circuit operates in a first mode or a second mode, attenuates an input signal in the first mode, and passes the input signal in the second mode. The multiple attenuation circuits may provide the same or different amounts of attenuation. The multiple attenuation circuits may include binary decoded attenuation circuits and/or thermometer decoded attenuation circuits. In one design, each attenuation circuit includes a divider circuit and at least one switch. The switch(es) select the first mode or the second mode. The divider circuit attenuates an input signal in the first mode and passes the input signal in the second mode. The programmable gain circuit may have a predetermined input impedance and a predetermined output impedance for all gain settings.