An X-ray diagnostic imaging system is disclosed that includes an X-ray source for controlling an X-ray beam radiated towards a patient under examination. The X-ray source includes an X-ray tube and X-ray collimator assembly. The system includes an-ray imaging device arranged for receiving the X-ray beam after is has passed through the patient to acquire latent image frames of a region of interest (ROI) of the patient's anatomy, and a system controller coupled to X-ray source and X-ray imaging device for controlling latent image frame acquisition and post-acquisition processing. The controlling includes controlling the X-ray imaging device and X-ray positioning, and collimator assembly operation. An image processing chain including an image processor coupled to the system controller, receives latent image frames from the X-ray imaging device for processing, including calculating a histogram from which pixels within a collimated area are removed. The improved histogram is used in post-acquisition processing such as a window level setting. An X-ray image processed by functions using the improved histogram is displayed by a display device coupled to the image processing chain.