A self-sealed medical sterilization pouch comprises the following elements of: a first sheet being pervious to sterilization gases and surrounded by at least one printing domain thereon, a plurality of signs being disposed on the printing domain and located outside of a closed space, the first sheet having at least two sterile processing indicators having color response, one surface of an end of the first sheet having a flap; and a second sheet being impervious to sterilization gases, the second sheet having an opening and being joined with the first sheet by a first seal line, a second seal line and a third seal line at a left side, a right side and an upper side to form the closed space, the sterile processing indicators being disposed between the third seal line and a ladle-shaped end and the third seal line and another ladle-shaped end respectively.