Invention Grant
US07871786B2 GEF-H1b: biomarkers, complexes, assays and therapeutic uses thereof
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GEF-H1b：生物标志物，复合物，测定及其治疗用途
- Patent Title: GEF-H1b: biomarkers, complexes, assays and therapeutic uses thereof
- Patent Title (中): GEF-H1b：生物标志物，复合物，测定及其治疗用途
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Application No.: US12232134Application Date: 2008-09-11
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Publication No.: US07871786B2Publication Date: 2011-01-18
- Inventor: Tod R. Smeal , Marinella G. Callow , Bahija Jallal , Sergey Zozulya , Mikhail L. Gishizky
- Applicant: Tod R. Smeal , Marinella G. Callow , Bahija Jallal , Sergey Zozulya , Mikhail L. Gishizky
- Applicant Address: US NY New York
- Assignee: Sugen, Inc.
- Current Assignee: Sugen, Inc.
- Current Assignee Address: US NY New York
- Agent Austin W. Zhang; Jeffrey H. Tidwell
- Main IPC: G01N33/53
- IPC: G01N33/53 ; A61K39/395 ; C07K16/00 ; C07K5/00
Abstract:
The present invention relates to diagnosing abnormal cell proliferation in biological samples and screening for drugs which inhibit, reduce or abolish cell growth, especially tumorigenic cell growth, by detecting a phosphovariant isoform of a guanine nucleotide exchange factor biomarker, such as the novel GEF-H1S.
Public/Granted literature
- US20090130695A1 GEF-H1b: biomarkers, complexes, assays and therapeutic uses thereof Public/Granted day:2009-05-21
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