Invention Grant
US07871817B2 Method for rational mutagenesis of α/β t-cell receptors and correspondingly mutated mdm2-protein specific α/β t-cell receptors
有权
α/ bgr的合理诱变方法 t细胞受体和相应突变的mdm2蛋白特异性α/ bgr; t细胞受体
- Patent Title: Method for rational mutagenesis of α/β t-cell receptors and correspondingly mutated mdm2-protein specific α/β t-cell receptors
- Patent Title (中): α/ bgr的合理诱变方法 t细胞受体和相应突变的mdm2蛋白特异性α/ bgr; t细胞受体
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Application No.: US10529072Application Date: 2003-09-24
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Publication No.: US07871817B2Publication Date: 2011-01-18
- Inventor: Ralf-Holger Voss , Theobald Matthias
- Applicant: Ralf-Holger Voss , Theobald Matthias
- Applicant Address: DE Mainz
- Assignee: Johannes Gutenberg-Universitat Mainz
- Current Assignee: Johannes Gutenberg-Universitat Mainz
- Current Assignee Address: DE Mainz
- Agency: Saliwanchik, Lloyd & Saliwanchik
- Priority: DE10244457 20020924
- International Application: PCT/EP03/10633 WO 20030924
- International Announcement: WO2004/029085 WO 20040408
- Main IPC: C12N15/63
- IPC: C12N15/63 ; C07K1/00 ; C07K14/00 ; C07H21/04
Abstract:
The invention relates to the rational mutagenesis of polypeptides of α/β T-cell receptors that mediate an oncogen-specific T-cell response, nucleic acids encoding these and their use in the therapy, diagnosis and/or prevention of cancerous diseases. The invention further relates to a T-cell response-mediating MDM2-protein-specific α/β T-cell receptor, which has been rationally mutated by means of the method according to the present invention, and the uses thereof.
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