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US07872144B2 Process for producing biphosphonic acids and forms thereof 有权
制备双膦酸的方法及其形式

Process for producing biphosphonic acids and forms thereof
Abstract:
Disclosed herein is a process for producing bisphosphonic acids and salts thereof. The process comprising reacting a carboxylic acid of Formula [I] with phosphorous acid and halophosphorus compound in the presence of a solvent selected from aliphatic hydrocarbon or water miscible cyclic ether. Further, the present invention also provides novel forms of bisphosphonic acids and process for preparation thereof.
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