Disclosed is a method of controlling a transmit power constraint at a mobile station using a pilot power ratio (PPR) or other measurement of relative received powers (or signal strengths) between a neighbor cell transmission and a serving cell transmission such that other-cell interference produced by the mobile station may be managed. The transmit power constraint may, for example, correspond to a total or per sub-carrier maximum allowable mobile station transmit power. The transmit power constraint may be decreased if an adjacent neighbor cell, or an adjacent neighbor cell with a strongest pilot signal strength at the mobile station, is interference overloaded, i.e., interference levels in the adjacent neighbor cell is above a threshold interference level. Such decrease may be based on a pilot power ratio between a received pilot power of the overloaded adjacent neighbor cell at the mobile station and a received pilot power of the serving cell at the mobile station. Conversely, the transmit power constraint may be decreased if at least one adjacent neighbor cell, or the adjacent neighbor cell with the strongest pilot signal strength at the mobile station, is not interference overloaded. Such increase may be based on a pilot power ratio between a received pilot power of the adjacent neighbor cell with the strongest pilot signal strength at the mobile station and a received pilot power of the serving cell at the mobile station.