The digital signal amplifier and acquisition system includes at least one catheter input module (CIM) configured to receive, route and digitize incoming analog cardiac signals from a number of catheters, as well as outgoing stimulator pulses. A plurality of CIMs are mechanically stacked and electrically daisy-chained and coupled with a mounting. The mounting platter is clamped to the bedrail and provides a single digital output cable to the base. The system also includes an acquisition device and the aforementioned base, which is configured to collect, filter and distribute the acquired data. Lastly an analog output module receives filtered digital signals from the base and is configured to reconstruct analog representations of such filtered digital signals for outside devices.