Invention Grant
US07875631B2 Tetrahydroisoquinoline-and tetrahydrobenzazepine derivatives as igf-1 r inhibitors
有权
四氢异喹啉和四氢苯并吖庚因衍生物作为igf-1r抑制剂
- Patent Title: Tetrahydroisoquinoline-and tetrahydrobenzazepine derivatives as igf-1 r inhibitors
- Patent Title (中): 四氢异喹啉和四氢苯并吖庚因衍生物作为igf-1r抑制剂
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Application No.: US10591174Application Date: 2004-03-12
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Publication No.: US07875631B2Publication Date: 2011-01-25
- Inventor: Jan Gunzinger , Kurt Leander
- Applicant: Jan Gunzinger , Kurt Leander
- Applicant Address: CH Couvet
- Assignee: Analytecon S.A.
- Current Assignee: Analytecon S.A.
- Current Assignee Address: CH Couvet
- Agency: Harness, Dickey & Pierce, P.L.C.
- International Application: PCT/CH2004/000147 WO 20040312
- International Announcement: WO2005/087743 WO 20050922
- Main IPC: C07D217/02
- IPC: C07D217/02 ; A61K31/47
Abstract:
Compounds of the formula (I): where R2, R5, R6 have the meanings as given in the description, and U, V and W, respectively, may be CR2′, CR4′ and CR6′, respectively (with the definitions of R2′, R4′ and R6′ again as in the description), or may be N, were synthesized. They were found to down-regulate or inhibit the expression or function of the IGF-1 receptor.
Public/Granted literature
- US20070129399A1 Tetrahydroisoquinoline-and tetrahydrobenzazepine derivatives as igf-1r inhibitors Public/Granted day:2007-06-07
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