Invention Grant
- Patent Title: Inhibitors of folic acid-dependent enzymes
- Patent Title (中): 叶酸依赖酶抑制剂
-
Application No.: US12080844Application Date: 2008-04-07
-
Publication No.: US07875716B2Publication Date: 2011-01-25
- Inventor: Dan Stoicescu
- Applicant: Dan Stoicescu
- Agency: Wolf, Greenfield & Sacks, P.C.
- Priority: EP05107582 20050817
- Main IPC: C07D475/00
- IPC: C07D475/00 ; C07D487/00

Abstract:
The invention relates to compounds of the formula I, or pharmaceutically acceptable salts thereof: wherein: Z=O or S; n=1-3; R3=—CO2R8, —C(O)SR8, —C(O)NHR8, —C(S)OR8, —C(S)SR8, —C(S)NHR8, —C(NH)SR8 or —C(NH)NHR8, wherein R8 is —H or alkyl; R4=—H, —CH2R5 or —CH2CH2R5, wherein R5 independently has one of the meanings of R3; B=—NR2—, —CH2NR2—, —CH2CH2NR2—, —CH2CHR7— or —CH2O—, wherein R2 is H or a C1-3 alkyl, alkenyl or alkynyl group, and R7 is H or a C1-3 alkyl or alkoxy group; wherein R1=—NH2 or —OH, and C and D are each, independently, a 5- or 6-membered, substituted or unsubstituted, aromatic or non-aromatic ring which may also contain one or more heteroatoms, and C is connected to group B in any available position.
Public/Granted literature
- US20080214550A1 Novel inhibitors of folic acid-dependent enzymes Public/Granted day:2008-09-04
Information query
IPC分类:
C | 化学;冶金 |
C07 | 有机化学 |
C07D | 杂环化合物(高分子化合物入C08) |
C07D475/00 | 含蝶啶环系的杂环化合物 |