The invention relates to protective clothing with a protective function against chemical and/or biological contaminants, especially for civil or military purposes, such as NBC protective clothing, with the protective clothing having a multiple-layer construction or a multiple-ply textile construction with an outer material and an inner material equipped with a protective function against chemical and/or biological contaminants, with the protective clothing being provided with at least one ventilation opening that is closed with a gas-permeable, in particular, air-permeable protective filter material that sorbs chemical and/or biological contaminants. In this way, when the clothing is being worn, the air supply and the air exchange is increased in an efficient way and the removal of moisture, in particular, sweat, and also excess body heat, is improved and thus the overall comfort in wearing the clothing is increased, without negatively affecting the protective function of the clothing.