A radiation image photographing apparatus is formed with a photographing unit that includes a radiation emission means for emitting radiation, a radiation image detection means for recording a radiation image, a region of interest indication means for indicating a mark on a site of a subject corresponding to the region of interest specified in the radiation image, and the like; a computer having an input means, such as a mouse; and a monitor, in which a radiation image obtained by photographing is displayed on the monitor to have the user to specify a region of interest through the input means, and when coordinate information of the region of interest in the image is received from the computer, photographing unit, based on this, controls the region of interest indication means to automatically indicate a mark on a site of the subject corresponding to the region of interest.