Invention Grant
- Patent Title: Composition and method for inducing bone growth and healing
- Patent Title (中): 用于诱导骨生长和愈合的组合物和方法
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Application No.: US10504652Application Date: 2003-02-20
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Publication No.: US07879107B2Publication Date: 2011-02-01
- Inventor: Melissa L. Knothe Tate , Ulf R. Knothe
- Applicant: Melissa L. Knothe Tate , Ulf R. Knothe
- Applicant Address: US OH Cleveland
- Assignee: The Cleveland Clinic Foundation
- Current Assignee: The Cleveland Clinic Foundation
- Current Assignee Address: US OH Cleveland
- Agency: Pearne & Gordon LLP
- International Application: PCT/US03/04858 WO 20030220
- International Announcement: WO03/070186 WO 20030828
- Main IPC: A61F2/28
- IPC: A61F2/28

Abstract:
A composition and method for inducing bone growth and healing is provided. The composition is useful for promoting new bone synthesis, and to enhance the mechanical stability and longevity of orthopaedic implants. The composition includes a bone endogenous material which is used as raw material for the body's natural osteogenic mechanism to synthesize new bone. The composition is applied in a flow phase and then undergoes a phase change to a congealed phase. The resulting material has a dual mode porosity system, having a first order porosity to accommodate and promote convective diffusion of nutrient species into and through the material, and a second order porosity to accommodate osteoblastic migration therein without the need for osteoclastic resorption.
Public/Granted literature
- US20050107887A1 Composition and method for inducing bone growth and healing Public/Granted day:2005-05-19
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