Invention Grant
- Patent Title: Compositions and methods for use for antibodies against sclerostin
- Patent Title (中): 用于抗硬化性抗体的组合物和方法
-
Application No.: US12249050Application Date: 2008-10-10
-
Publication No.: US07879322B2Publication Date: 2011-02-01
- Inventor: Michaela Kneissel , Christine Halleux , Shou-Ih Hu , Beate Diefenbach-Streiber , Josef Prassler
- Applicant: Michaela Kneissel , Christine Halleux , Shou-Ih Hu , Beate Diefenbach-Streiber , Josef Prassler
- Applicant Address: CH Basel
- Assignee: Novartis AG
- Current Assignee: Novartis AG
- Current Assignee Address: CH Basel
- Agent Leslie Fischer
- Priority: EP07118414 20071012; EP08151911 20080225; EP08161342 20080729
- Main IPC: A61K39/00
- IPC: A61K39/00 ; A61K39/395 ; C07K16/00 ; C07K16/18 ; C07K16/22 ; C07K16/24 ; C07K16/26 ; C12N15/13 ; C12N15/63 ; G01N33/53
Abstract:
The present invention relates to antibodies against sclerostin and compositions and methods of use for said antibodies to treat disease related to bone abnormalities such as osteoporosis. An embodiment of the invention herein provides an antibody or a functional protein comprising an antigen-binding portion of said antibody for a target in sclerostin polypeptide, characterized in that the antibody or functional protein specifically binds to sclerostin polypeptide and can increase at least one of bone formation, bone mineral density, bone mineral content, bone mass, bone quality and bone strength in a mammal.
Public/Granted literature
- US20090130113A1 Compositions and methods for use for antibodies against sclerostin Public/Granted day:2009-05-21
Information query
