Invention Grant
US07879338B2 Vectors and methods for immunization against norovirus using transgenic plants
有权
使用转基因植物免疫诺如病毒的载体和方法
- Patent Title: Vectors and methods for immunization against norovirus using transgenic plants
- Patent Title (中): 使用转基因植物免疫诺如病毒的载体和方法
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Application No.: US10895791Application Date: 2004-07-21
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Publication No.: US07879338B2Publication Date: 2011-02-01
- Inventor: William D.O. Hamilton , Koen Hellendoorn , Timothy D. Jones , Dwayne D. Kirk , Hugh S. Mason , Xiuren Zhang , Charles J. Arntzen
- Applicant: William D.O. Hamilton , Koen Hellendoorn , Timothy D. Jones , Dwayne D. Kirk , Hugh S. Mason , Xiuren Zhang , Charles J. Arntzen
- Applicant Address: US NY Ithaca
- Assignee: Boyce Thompson Institute for Plant Research
- Current Assignee: Boyce Thompson Institute for Plant Research
- Current Assignee Address: US NY Ithaca
- Agency: Nixon Peabody LLP
- Main IPC: C12N15/40
- IPC: C12N15/40 ; C12N5/04 ; C12N1/21 ; A61K39/125 ; A01H5/00 ; A01H5/08 ; A01H5/10
Abstract:
The present invention relates to a synthetic plant-optimized nucleic acid molecule having a Norwalk virus capsid protein coding nucleotide sequence, and nucleic acid constructs, host cells, expression systems, and plants having the plant-optimized Norwalk virus nucleic acid molecule. The present invention also relates to a method of producing Norwalk virus capsid protein virus-like particles in a transgenic plant or transgenic plant seed transformed with a plant-optimized nucleic acid molecule encoding Norwalk virus capsid protein. The plant or a component thereof can be administered to a subject under conditions effective to immunize the subject against disease resulting from infection by a Norovirus, including Norwalk virus. An oral vaccine for immunization of a subject against Norwalk virus infection is also disclosed.
Public/Granted literature
- US20050155113A1 Vectors and methods for immunization against Norwalk virus using transgenic plants Public/Granted day:2005-07-14
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