Invention Grant
US07879388B2 Methods for production and use of synthetic hydroxyapatite and fluorapatite nanorods, and superstructures assembled from the same
有权
合成羟基磷灰石和氟磷灰石纳米棒的生产和使用方法，以及由其组装的上层结构
- Patent Title: Methods for production and use of synthetic hydroxyapatite and fluorapatite nanorods, and superstructures assembled from the same
- Patent Title (中): 合成羟基磷灰石和氟磷灰石纳米棒的生产和使用方法，以及由其组装的上层结构
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Application No.: US11665529Application Date: 2005-10-28
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Publication No.: US07879388B2Publication Date: 2011-02-01
- Inventor: Brian H. Clarkson , Haifeng Chen
- Applicant: Brian H. Clarkson , Haifeng Chen
- Applicant Address: US MI Ann Arbor
- Assignee: The Regents of the University of Michigan
- Current Assignee: The Regents of the University of Michigan
- Current Assignee Address: US MI Ann Arbor
- Agency: Marshall, Gerstein & Borun LLP
- International Application: PCT/US2005/039492 WO 20051028
- International Announcement: WO2006/050365 WO 20060511
- Main IPC: A61L27/32
- IPC: A61L27/32 ; C01B25/32
Abstract:
Disclosed herein are methods directed toward the synthesis of ordered structures of hydroxyapatite and hydroxyapatite derivatives. More specifically, disclosed herein is a method of preparing ordered hydroxyapatite nanorod structures including the steps of suspending calcium and phosphate in a solvent, adjusting the pH to above 5, and heating to a temperature sufficient to support formation of the ordered hydroxyapatite nanorod structures. In some cases, the methods may include ethylenediamine tetraacetic acid or ethylenediamine tetraacetic acid derivatives. Also disclosed are methods that additionally involve a step of coating hydroxyapatite nanorods with a protein or an amphiphile such as a surfactant or polymer.
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