Invention Grant
US07879545B2 Identification of novel targets for radio sensitization using a genomic-based radiation sensitivity classifier
有权
使用基于基因组的辐射敏感性分类器鉴定无线电敏化的新靶标
- Patent Title: Identification of novel targets for radio sensitization using a genomic-based radiation sensitivity classifier
- Patent Title (中): 使用基于基因组的辐射敏感性分类器鉴定无线电敏化的新靶标
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Application No.: US10904326Application Date: 2004-11-04
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Publication No.: US07879545B2Publication Date: 2011-02-01
- Inventor: Javier F. Torres-Roca , Timothy Yeatman , Steven Eschrich
- Applicant: Javier F. Torres-Roca , Timothy Yeatman , Steven Eschrich
- Applicant Address: US FL Tampa US FL Tampa
- Assignee: H. Lee Moffitt Cancer Center and Research Institute, Inc.,University of South Florida
- Current Assignee: H. Lee Moffitt Cancer Center and Research Institute, Inc.,University of South Florida
- Current Assignee Address: US FL Tampa US FL Tampa
- Agency: Smith & Hopen, P.A.
- Agent Robert Varkonyi
- Main IPC: C12Q1/68
- IPC: C12Q1/68 ; G01N33/53
Abstract:
A classifier to predict cellular radiation sensitivity based on gene expression profiles in thirty-five cell lines from the NCI panel of 60 cancer cell lines (NCI-60), using a novel approach to predictive gene analysis. Three novel genes are provided, retinoblastoma binding protein 4 (RbAp48), G-protein signaling regulator 19 (RGS19) and ribose-5-phosphate isomerase A (R5PIA) whose expression values were correlated with radiation sensitivity.
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