Invention Grant
- Patent Title: Enhancement of tigecycline potency using efflux pump inhibitors
- Patent Title (中): 使用外排泵抑制剂增强替加环素效力
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Application No.: US11832626Application Date: 2007-08-01
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Publication No.: US07879795B2Publication Date: 2011-02-01
- Inventor: Tomasz Glinka , Keith Bostian , Olga Lomovskaya , Mark Surber , Dongxu Sun
- Applicant: Tomasz Glinka , Keith Bostian , Olga Lomovskaya , Mark Surber , Dongxu Sun
- Applicant Address: US CA San Diego
- Assignee: Mpex Pharmaceuticals, Inc.
- Current Assignee: Mpex Pharmaceuticals, Inc.
- Current Assignee Address: US CA San Diego
- Agency: Knobbe, Martens, Olsen & Bear LLP
- Main IPC: A61K38/00
- IPC: A61K38/00
Abstract:
Disclosed herein are Efflux Pump Inhibitor (EPI) compounds that can be co-administered with antimicrobial agents for the treatment of infections caused by drug resistant pathogens. The EPI compounds are soft drugs which exhibit a reduced propensity for tissue accumulation. It is demonstrated that the EPIs can be used to increase the potency, decrease bacterial resistance and development of bacterial resistance, and increase killing effectivness of tigecycline. Also disclosed are methods of treatment and pharmaceutical compositions for co-administering tigecylcine with an EPI.
Public/Granted literature
- US20080076741A1 ENHANCEMENT OF TIGECYCLINE POTENCY USING EFFLUX PUMP INHIBITORS Public/Granted day:2008-03-27
Information query
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