Invention Grant
US07879808B2 Lincomycin derivatives and antimicrobial agents comprising the same as active ingredient
失效
林可霉素衍生物和包含与活性成分相同的抗微生物剂
- Patent Title: Lincomycin derivatives and antimicrobial agents comprising the same as active ingredient
- Patent Title (中): 林可霉素衍生物和包含与活性成分相同的抗微生物剂
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Application No.: US12451744Application Date: 2008-05-30
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Publication No.: US07879808B2Publication Date: 2011-02-01
- Inventor: Yoshinari Wakiyama , Kou Kumura , Satomi Masaki , Kazutaka Ueda , Yasuo Sato , Chika Kikuchi , Eijirou Umemura , Yoko Hirai , Hiroshi Kondo
- Applicant: Yoshinari Wakiyama , Kou Kumura , Satomi Masaki , Kazutaka Ueda , Yasuo Sato , Chika Kikuchi , Eijirou Umemura , Yoko Hirai , Hiroshi Kondo
- Applicant Address: JP Tokyo-To
- Assignee: Meiji Seika Kaisha, Ltd.
- Current Assignee: Meiji Seika Kaisha, Ltd.
- Current Assignee Address: JP Tokyo-To
- Agency: Wenderoth, Lind & Ponack, L.L.P.
- Priority: JP2007-146192 20070531
- International Application: PCT/JP2008/060042 WO 20080530
- International Announcement: WO2008/146917 WO 20081204
- Main IPC: A01N43/04
- IPC: A01N43/04 ; A61K31/70 ; C07H15/16

Abstract:
An objective of the present invention is to provide compounds of formula (1) or their pharmacologically acceptable salts or solvates wherein A represents aryl; R1 represents N-optionally substituted C1-6 alkyl-N-optionally substituted C1-6 alkylamino-C1-6 alkyl; R2 represents a hydrogen atom or optionally substituted C1-6 alkyl; R3 represents optionally substituted C1-6 alkyl or C3-6 cycloalkyl-C1-4 alkyl; m is 1 to 3; n is 0; and p is 0 to 2. The compounds are novel lincomycin derivatives that have a potent activity against resistant Streptococcus pneumoniae, which have recently posed problems, in the treatment of infectious diseases. Further, the compounds are usable as antimicrobial agents and are useful for preventing or treating bacterial infectious diseases.
Public/Granted literature
- US20100210570A1 LINCOMYCIN DERIVATIVES AND ANTIMICROBIAL AGENTS COMPRISING THE SAME AS ACTIVE INGREDIENT Public/Granted day:2010-08-19
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