Invention Grant
- Patent Title: Immunomodulatory oligonucleotides and methods of use therefor
- Patent Title (中): 免疫调节寡核苷酸及其使用方法
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Application No.: US12185418Application Date: 2008-08-04
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Publication No.: US07879812B2Publication Date: 2011-02-01
- Inventor: Robert Ashman , Petar Lenert
- Applicant: Robert Ashman , Petar Lenert
- Applicant Address: US IA Iowa City
- Assignee: University of Iowa Research Foundation
- Current Assignee: University of Iowa Research Foundation
- Current Assignee Address: US IA Iowa City
- Agency: Fulbright & Jaworski
- Main IPC: A01N43/04
- IPC: A01N43/04 ; C12Q1/68 ; C12P19/34 ; C12N15/63 ; C07H21/02
Abstract:
The present invention is drawn a new class of oligodeoxynucleotides (ODNs) that inhibit ODN-activation of Toll-like receptor (TLR)9. Particular 4-5 base extensions at the 5′ and of the previously described core inhibitory ODN sequence enhances their inhibitory activity against human cells expressing human TLR9. Methods of use also are provided.
Public/Granted literature
- US20100081706A1 IMMUNOMODULATORY OLIOGONUCLEOTIDES AND METHODS OF USE THEREFOR Public/Granted day:2010-04-01
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