Invention Grant
US07879826B2 Derivatives of [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)alkyl]phosphonic acid and methods of making them
失效
[2-(8,9-二氧代-2,6-二氮杂双环[5.2.0]壬-1(7) - 烯-2-基)烷基]膦酸的衍生物及其制备方法
- Patent Title: Derivatives of [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)alkyl]phosphonic acid and methods of making them
- Patent Title (中): [2-(8,9-二氧代-2,6-二氮杂双环[5.2.0]壬-1(7) - 烯-2-基)烷基]膦酸的衍生物及其制备方法
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Application No.: US11758459Application Date: 2007-06-05
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Publication No.: US07879826B2Publication Date: 2011-02-01
- Inventor: Reinhardt Bernhard Baudy
- Applicant: Reinhardt Bernhard Baudy
- Applicant Address: US NJ Madison
- Assignee: Wyeth LLC
- Current Assignee: Wyeth LLC
- Current Assignee Address: US NJ Madison
- Agent Joel Silver
- Main IPC: A61P25/00
- IPC: A61P25/00 ; A61K31/675 ; C07D223/00
![Derivatives of [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)alkyl]phosphonic acid and methods of making them](/abs-image/US/2011/02/01/US07879826B2/abs.jpg.150x150.jpg)
Abstract:
Compounds of formula (I) or pharmaceutically acceptable salts thereof are provided: wherein: A is alkylenyl of 1 to 4 carbon atoms, or alkenylenyl of 2 to 4 carbon atoms; R1 and R2 are, independently, hydrogen or a C5 to C7 aryl optionally substituted with 1 to 2 substituents, independently, selected from the group consisting of —C(O)R3, halogen, cyano, nitro, hydroxyl, C1-C6 alkyl, and C1-C6 alkoxy, with the proviso that at least one of R1 and R2 is not hydrogen; R3 is, independently, hydrogen, —OR4, alkyl, aryl, or heteroaryl; R4 is hydrogen, alkyl, aryl, or heteroaryl; R5 and R6 are, independently, hydrogen, alkyl, hydroxyl, alkoxy, or C5 to C7 aryl; wherein any R3 to R6 group having an aryl or heteroaryl moiety can optionally be substituted on the aryl or heteroaryl moiety with 1 to about 5 substituents, independently, selected from the group consisting of halogen, cyano, nitro, hydroxyl, C1-C6 alkyl, and C1-C6 alkoxy. Methods of making these compounds as well as methods using the compounds for treating a variety of conditions are also disclosed.
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