Invention Grant
US07879826B2 Derivatives of [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)alkyl]phosphonic acid and methods of making them 失效
[2-(8,9-二氧代-2,6-二氮杂双环[5.2.0]壬-1(7) - 烯-2-基)烷基]膦酸的衍生物及其制备方法

  • Patent Title: Derivatives of [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)alkyl]phosphonic acid and methods of making them
  • Patent Title (中): [2-(8,9-二氧代-2,6-二氮杂双环[5.2.0]壬-1(7) - 烯-2-基)烷基]膦酸的衍生物及其制备方法
  • Application No.: US11758459
    Application Date: 2007-06-05
  • Publication No.: US07879826B2
    Publication Date: 2011-02-01
  • Inventor: Reinhardt Bernhard Baudy
  • Applicant: Reinhardt Bernhard Baudy
  • Applicant Address: US NJ Madison
  • Assignee: Wyeth LLC
  • Current Assignee: Wyeth LLC
  • Current Assignee Address: US NJ Madison
  • Agent Joel Silver
  • Main IPC: A61P25/00
  • IPC: A61P25/00 A61K31/675 C07D223/00
Derivatives of [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)alkyl]phosphonic acid and methods of making them
Abstract:
Compounds of formula (I) or pharmaceutically acceptable salts thereof are provided: wherein: A is alkylenyl of 1 to 4 carbon atoms, or alkenylenyl of 2 to 4 carbon atoms; R1 and R2 are, independently, hydrogen or a C5 to C7 aryl optionally substituted with 1 to 2 substituents, independently, selected from the group consisting of —C(O)R3, halogen, cyano, nitro, hydroxyl, C1-C6 alkyl, and C1-C6 alkoxy, with the proviso that at least one of R1 and R2 is not hydrogen; R3 is, independently, hydrogen, —OR4, alkyl, aryl, or heteroaryl; R4 is hydrogen, alkyl, aryl, or heteroaryl; R5 and R6 are, independently, hydrogen, alkyl, hydroxyl, alkoxy, or C5 to C7 aryl; wherein any R3 to R6 group having an aryl or heteroaryl moiety can optionally be substituted on the aryl or heteroaryl moiety with 1 to about 5 substituents, independently, selected from the group consisting of halogen, cyano, nitro, hydroxyl, C1-C6 alkyl, and C1-C6 alkoxy. Methods of making these compounds as well as methods using the compounds for treating a variety of conditions are also disclosed.
Information query
Patent Agency Ranking
0/0