Invention Grant
US07879893B2 Ligands for the HisB10 Zn2 + sites of the R-state insulin hexamer
有权
用于R-state胰岛素六聚体的HisB10 Zn2 +位点的配体
- Patent Title: Ligands for the HisB10 Zn2 + sites of the R-state insulin hexamer
- Patent Title (中): 用于R-state胰岛素六聚体的HisB10 Zn2 +位点的配体
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Application No.: US10332541Application Date: 2002-09-13
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Publication No.: US07879893B2Publication Date: 2011-02-01
- Inventor: Helle Birk Olsen , Niels C. Kaarsholm , Peter Madsen , Soren Ostergaard , Svend Ludvigsen , Palle Jakobsen , Anders Klarskov Petersen , Dorte Bjerre Steensgaard
- Applicant: Helle Birk Olsen , Niels C. Kaarsholm , Peter Madsen , Soren Ostergaard , Svend Ludvigsen , Palle Jakobsen , Anders Klarskov Petersen , Dorte Bjerre Steensgaard
- Applicant Address: DK Bagsvaerd
- Assignee: Novo Nordisk A/S
- Current Assignee: Novo Nordisk A/S
- Current Assignee Address: DK Bagsvaerd
- Agent Rosemarie R. Wilk-Orescan
- Priority: DK200101337 20010914; DK200201066 20020705
- International Application: PCT/DK02/00595 WO 20020913
- International Announcement: WO03/027081 WO 20030403
- Main IPC: A61K31/41
- IPC: A61K31/41 ; A61K31/40 ; C07D257/00 ; C07D209/82
Abstract:
The present invention relates to novel ligands for the HisB10 Zn2+ sites of the R-state insulin hexamer having the formula A-B-C-D-X (III), wherein: A is a chemical group which reversibly binds to a HisB10 Zn2+ sites of an insulin hexamer; B is a linker; C is a fragment consisting of 0 to 5 neutral amino acids; D is a fragment comprising 1 to 20 positively charged groups independently selected from amino or guanidino groups; and X is —OH, —NH2 or a diamino group. The present invention also relates to R-state insulin hexamers comprising such ligands, and aqueous insulin preparations comprising such R-state insulin hexamers.
Public/Granted literature
- US20030229120A1 Novel ligands for the hisb10 zn2+ sites of the r-state insulin hexamer Public/Granted day:2003-12-11
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