Invention Grant
- Patent Title: Dual-acting imidazole antihypertensive agents
- Patent Title (中): 双效咪唑降压药
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Application No.: US12148842Application Date: 2008-04-23
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Publication No.: US07879896B2Publication Date: 2011-02-01
- Inventor: Paul Allegretti , Seok-Ki Choi , Roland Gendron , Paul R. Fatheree , Keith Jendza , Robert Murray McKinnell , Darren McMurtrie , Brooke Olson
- Applicant: Paul Allegretti , Seok-Ki Choi , Roland Gendron , Paul R. Fatheree , Keith Jendza , Robert Murray McKinnell , Darren McMurtrie , Brooke Olson
- Applicant Address: US CA South San Francisco
- Assignee: Theravance, Inc.
- Current Assignee: Theravance, Inc.
- Current Assignee Address: US CA South San Francisco
- Agent Jeffrey A. Hagenah; Shelley Eberle
- Main IPC: A61K31/4164
- IPC: A61K31/4164 ; C07D233/54
Abstract:
The invention is directed to compounds having the formula: wherein: Ar, r, R2-3, X, and R5-7 are as defined in the specification, and pharmaceutically acceptable salts thereof. These compounds have AT1 receptor antagonist activity and neprilysin inhibition activity. The invention is also directed to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.
Public/Granted literature
- US20090023228A1 Dual-acting Imidazole antihypertensive agents Public/Granted day:2009-01-22
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