Invention Grant
US07879904B2 9, 10-α,α-OH-taxane analogs and methods for production thereof
有权
9,10-α,α-OH-紫杉烷类似物及其制备方法
- Patent Title: 9, 10-α,α-OH-taxane analogs and methods for production thereof
- Patent Title (中): 9,10-α,α-OH-紫杉烷类似物及其制备方法
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Application No.: US12792427Application Date: 2010-06-02
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Publication No.: US07879904B2Publication Date: 2011-02-01
- Inventor: Jan Zygmunt , James Ferrara , James D. McChesney
- Applicant: Jan Zygmunt , James Ferrara , James D. McChesney
- Applicant Address: US CO Boulder
- Assignee: Tapestry Pharmaceuticals, Inc.
- Current Assignee: Tapestry Pharmaceuticals, Inc.
- Current Assignee Address: US CO Boulder
- Agency: Morgan, Lewis & Bockius LLP
- Main IPC: A61K31/337
- IPC: A61K31/337 ; A61K31/427

Abstract:
The present invention relates to a method for the treatment of cancer in a cancer patient. In particular, the invention provides a method for the treatment comprising administering a taxane compound to a cancer patient, wherein the taxane compound is made by a process comprising treating a first compound represented by either Formula G′ or Formula M′: with a second compound of generalized formula R8R9C(OCH3)2 and an acid selected from the group consisting of camphor sulfonic acid (CSA), p-toluene sulfonic acid (PTSA), hydrochloric acid (HCl) and acetic acid (AcOH), wherein R1 and R2 are each selected from H, an alkyl group, an olefinic group, an aromatic group, an O-alkyl group, an O-olefinic group, or an O-aromatic group; R7 is an alkyl group, an olefinic group, or an aromatic group; P1 is a hydroxyl protecting group; P5 is H or an acid labile protecting group at the 7-O position; R8 is H, alkyl group, olefinic or aromatic group; and R9 is: H, alkyl group, olefinic or aromatic or is as defined in the specification.
Public/Granted literature
- US20100324128A1 9, 10-Alpha, Alpha-OH-Taxane Analogs and Methods for Production Thereof Public/Granted day:2010-12-23
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