Techniques for performing interference cancellation in a wireless (e.g., CDMA) communication system are described. For a single-sector interference canceller, received samples are processed (e.g., despread) to isolate a signal from a transmitter (e.g., a base station) and obtain input samples. The input samples are transformed based on a first transform (e.g., a fast Hadamard transform) to obtain received symbols for multiple orthogonal channels (e.g., Walsh bins). The received symbols for the multiple orthogonal channels are scaled with multiple gains to obtain scaled symbols. The gains may be related to the inverses of the power estimates for the orthogonal channels. The scaled symbols are transformed based on a second transform (e.g., an inverse fast Hadamard transform) to obtain output samples, which are processed (e.g., spread) to obtain interference-canceled samples having the signal from the transmitter suppressed.