A phase locked loop and power amplifier are integrated on single chip. To eliminate cross-talk between the components, a frequency translation block is introduced to change the output frequency of the PLL. To isolate the components from unwanted feedback, a high isolation buffer is introduced between the components. To further isolate the components, the voltage supply domains for each component is physically separated. Each separate voltage supply domain can include a separate high isolation ring, separate voltage regulator, and separate bandgap reference.