A profiler which spatially profiles a hydrophobicity distribution for the transmembrane protein based on a scaled hydrophobicity value, includes an identifier for identifying a residue external to a membrane and removing the residue to obtain a truncated structure comprising plural residue side-chains, and a calculator which calculates plural residue centroids for the plural residue side-chains, calculates a distribution of the plural residue centroids, and obtains a geometric center for the distribution.