A method and system for event-driven inventory disposition are disclosed. According to one embodiment, a method may include detecting a disposition event associated with a given one of a number of inventory items. The method may further include evaluating each of a number of disposition channels with respect to the given item in response to detecting the disposition event, and dependent upon the evaluation, selecting a particular disposition channel through which to dispose of the given item. In one particular implementation of the method, detecting the disposition event may include detecting an indication that an expected profitability of the given item is less than a threshold value.