A brake caliper, especially for motorcycle applications, comprises a main rigid body, which can be coupled with a portion of a structure or a vehicle, and defining at least one seat (5); at least one piston (4) slidingly housed in the respective seat (5) and associated with fluid sealing means (22) and with elastic means (19) acting between the piston (4) and the seat (5) to cause at least an action of elastic return to the piston (4) during the sliding thereof, and defining—in cooperation with the respective seat (5) wherein it is inserted and with the elastic means (19)—a first chamber (21) in fluid communication with actuation means. The piston (4) further exhibits a side surface (11) which delimits, in cooperation with a side surface (17) of the respective seat (5), with the sealing means (22) and with the elastic means (19), a second chamber (24), and finally comprising also tapping means to provide a fluid communication between the first chamber (21) and the second chamber (24).