A cartridge for an electrohydrodynamic spraying device and a spraying device incorporating the cartridge, where the cartridge includes a locking mechanism. The cartridge is disposable, and can contain therapeutic or other fluid products. The fluid is delivered from the cartridge by a shaft-mounted piston, while the locking mechanism can be selectively engaged with the shaft such that in the engaged position, the locking mechanism prevents the piston from advancing by inhibiting movement of the shaft. When the locking mechanism is disengaged from the shaft, the shaft and piston are free to move, such as in response to a power source in the spraying device. The selective engagement between the locking mechanism and the shaft during periods of inoperability of the spray device prevents the buildup of fluid pressure in the cartridge that otherwise could blurt out upon subsequent operation.