A method for optimizing the operation of a wind turbine is provided, the method comprising the steps of: (a) adjusting at least one control parameter of said wind turbine to a predetermined starting value; (b) measuring at least one response variable of said wind turbine and at least one further variable indicative of an ambient condition of the wind turbine; (c) repeating step (b) N times, wherein N is a predetermined integer, wherein said at least one control parameter is varied at each repetition; (d) determining a measured relation between the at least one control parameter with respect to the at least one response variable and the at least one further variable indicative of an ambient condition; (e) determining an optimized value of said at least one control parameter with respect to said response variable from said measured relation; (f) adjusting a set point of said at least one control parameter to said optimized value.