Invention Grant
- Patent Title: Polycationic polyrotaxanes capable of forming complexes with nucleic acids
- Patent Title (中): 能与核酸形成复合物的聚阳离子聚轮烷
-
Application No.: US11347001Application Date: 2006-02-03
-
Publication No.: US07883688B2Publication Date: 2011-02-08
- Inventor: Jun Li , Chuan Yang , Hongzhe Li , Xin Wang , Suat Hong Goh , Kam W. Leong
- Applicant: Jun Li , Chuan Yang , Hongzhe Li , Xin Wang , Suat Hong Goh , Kam W. Leong
- Applicant Address: SG Singapore SG Singapore
- Assignee: Agency for Science, Technology and Research,National University of Singapore
- Current Assignee: Agency for Science, Technology and Research,National University of Singapore
- Current Assignee Address: SG Singapore SG Singapore
- Agency: K & L Gates LLP
- Agent Stephanie Seidman; Frank J. Miskiel
- Main IPC: A61B5/055
- IPC: A61B5/055 ; C12N5/00 ; C12N5/02 ; A61K48/00
Abstract:
A polycation capable of forming a complex with a nucleic acid for carriage thereof. The polycation comprising at least one cyclic compound having a cavity. A polymer backbone is threaded into the cavity of the cyclic compound. A pair of bulky moieties cap the terminals of the polymer backbone to inhibit dethreading of the cyclic compound from the polymer backbone. In use, the net positive charge of said polycation enables a complex to form with nucleic acid.
Public/Granted literature
- US20060211643A1 Polycations capable of forming complexes with nucleic acids Public/Granted day:2006-09-21
Information query
