Invention Grant
US07883712B2 Identification of virulence associated regions RD1 and RD5 leading to improve vaccine of M. bovis BCG and M. microti 失效
鉴定毒力相关区域RD1和RD5,导致改进牛分枝杆菌BCG和M. microti的疫苗

Identification of virulence associated regions RD1 and RD5 leading to improve vaccine of M. bovis BCG and M. microti
Abstract:
The present invention relates to a strain of M. bovis BCG or M. microti, wherein said strain has integrated part or all of the RD1 region responsible for enhanced immunogenicity of the tubercle bacilli, especially the ESAT-6 and CFP-10 genes. These strains will be referred as the M bovis BCG::RDI or M. microti::RD1 strains and are useful as a new improved vaccine for preventing tuberculosis and as a therapeutical product enhancing the stimulation of the immune system for the treatment of bladder cancer. These strains are also useful for the expression and presentation of heterologous antigens and molecule that are of therapeutic or prophylactic interest.
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