Invention Grant
- Patent Title: Substituted piperidines that increase P53 activity and the uses thereof
- Patent Title (中): 增加P53活性的替代哌啶及其用途
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Application No.: US11769030Application Date: 2007-06-27
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Publication No.: US07884107B2Publication Date: 2011-02-08
- Inventor: Yao Ma , Brian Robert Lahue , Gerald W. Shipps, Jr. , Yaolin Wang , Stephane L. Bogen , Matthew Ernst Voss , Latha G. Nair , Yuan Tian , Ronald J. Doll , Zhuyan Guo , Corey O. Strickland , Rumin Zhang , Mark A. McCoy , Weidong Pan , Elise M. Siegel , Craig R. Gibeau
- Applicant: Yao Ma , Brian Robert Lahue , Gerald W. Shipps, Jr. , Yaolin Wang , Stephane L. Bogen , Matthew Ernst Voss , Latha G. Nair , Yuan Tian , Ronald J. Doll , Zhuyan Guo , Corey O. Strickland , Rumin Zhang , Mark A. McCoy , Weidong Pan , Elise M. Siegel , Craig R. Gibeau
- Applicant Address: US NJ Kenilworth
- Assignee: Merck
- Current Assignee: Merck
- Current Assignee Address: US NJ Kenilworth
- Agent Krishna G. Banerjee
- Main IPC: A61K31/54
- IPC: A61K31/54 ; C07D413/00 ; C07D403/00 ; C07D405/00
Abstract:
In its many embodiments, the present invention discloses novel compounds, as inhibitors of HDM2 protein methods for preparing such compounds, pharmaceutical compositions including one or more such compounds, methods of treatment, prevention, inhibition, of one or more diseases associated with the HDM2 protein or P53 using such compounds or pharmaceutical compositions.
Public/Granted literature
- US20080004287A1 Substituted Piperidines that Increase P53 Activity and the Uses Thereof Public/Granted day:2008-01-03
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