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Invention Grant
US07884125B2 Straightforward entry to 7-azabicyclo[2.2.1]heptane-1-carbonitriles and subsequent synthesis of epibatidine analogues 有权
直接进入7-氮杂双环[2.2.1]庚烷-1-碳腈并随后合成表阿巴定类似物

Straightforward entry to 7-azabicyclo[2.2.1]heptane-1-carbonitriles and subsequent synthesis of epibatidine analogues
Abstract:
The present invention relates to a group of substituted-7-azabicyclo-[2.2.1]heptyl derivatives with biological activity. The present invention also relates to synthetic methods for producing said substituted-7-azabicyclo-[2.2.1]heptyl derivatives. The present invention also relates to certain intermediates for producing such substituted-7-azabicyclo-[2.2.1]heptyl derivatives, as well as a synthetic method for producing such intermediates. The present invention also relates to pharmaceutical compositions comprising such substituted-7-azabicyclo-[2.2.1]heptyl derivatives, as well as their use as medicaments for the treatment of diseases mediated by a Nicotinic Acetylcholine Receptor or a receptor being a member of the Neurotransmitter-gated Ion Channel Superfamily, such as pain, Alzheimer's disease, Parkinson's disease, schizophrenia, epilepsy and nicotine addiction.
Abstract(Chinese):

本发明涉及一组具有生物活性的取代-7-氮杂双环 - [2.2.1]庚基衍生物。 本发明还涉及制备所述取代-7-氮杂双环[2.2.1]庚基衍生物的合成方法。 本发明还涉及用于制备这种取代的-7-氮杂双环[2.2.1]庚基衍生物的某些中间体以及用于生产这种中间体的合成方法。 本发明还涉及包含这种取代的-7-氮杂双环[2.2.1]庚基衍生物的药物组合物，以及它们作为用于治疗由烟碱乙酰胆碱受体介导的疾病或作为 神经递质门控离子通道超家族，如疼痛，阿尔茨海默病，帕金森病，精神分裂症，癫痫和尼古丁成瘾。

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