Invention Grant
US07884128B2 Process for total synthesis of pladienolide B and pladienolide D
失效
丙二烯内酯B和普拉二烯内酯D的全合成方法
- Patent Title: Process for total synthesis of pladienolide B and pladienolide D
- Patent Title (中): 丙二烯内酯B和普拉二烯内酯D的全合成方法
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Application No.: US12764336Application Date: 2010-04-21
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Publication No.: US07884128B2Publication Date: 2011-02-08
- Inventor: Regina Mikie Kanada , Daisuke Ito , Takashi Sakai , Naoki Asai , Yoshihiko Kotake , Jun Niijima
- Applicant: Regina Mikie Kanada , Daisuke Ito , Takashi Sakai , Naoki Asai , Yoshihiko Kotake , Jun Niijima
- Applicant Address: JP Tokyo
- Assignee: Eisai R&D Management Co., Ltd.
- Current Assignee: Eisai R&D Management Co., Ltd.
- Current Assignee Address: JP Tokyo
- Agency: Birch, Stewart, Kolasch & Birch, LLP
- Priority: JP2005-299228 20051013
- Main IPC: A61K31/36
- IPC: A61K31/36
Abstract:
Process for producing compound of Formula: wherein P2, P3 and R2 are the same as defined below, characterized by comprising reacting a compound represented by Formula (7): wherein P3 means a protecting group for hydroxy group; and Het means a 1-phenyl-1H-tetrazol-5-yl group, with a compound represented by Formula (8): wherein P2 means a protecting group for hydroxy group; and R2 means a phenyl group which may be substituted, in the presence of a base.
Public/Granted literature
- US20100204490A1 PROCESS FOR TOTAL SYNTHESIS OF PLADIENOLIDE B AND PLADIENOLIDE D Public/Granted day:2010-08-12
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