An interruption control system includes two sense elements, a microprocessor, and a controller. The microprocessor includes two registers, two flip-latches, a multiplexer, and a microcontroller. Each sense element senses a device and sends a sense signal. The corresponding register receives and stores the sense signal. The microcontroller sets an identity signal for each of the registers and controls the each of the flip-latch units to record a data signal of the device. The multiplexer alternately outputs the ID signals and the corresponding data signals to the microcontroller to encode into a datagram. The microcontroller sends the datagram to the controller. The controller is interrupted for decoding the datagram.