This disclosure describes systems and methods for a single-use oximetry sensor in which a single-use connector is used with the sensor assembly. The disclosure describes a connector which consists of a single-use male connector for use with female connector on an oximeter. The connector includes a housing enclosing one or more pins, one or more movable members, and a locking mechanism. Upon engagement of the male connector into the female connector the locking mechanism activates such that when the female connector is removed, the moveable member moves from a first position to a second position and locks into the second position. When in the second position the male connector can not engage the female connector, thereby limiting the male connector to a single use engagement.