Invention Grant
US07887808B2 Human Rgr oncogene and truncated transcripts thereof detected in T cell malignancies, antibodies to the encoded polypeptides and methods of use
有权
在T细胞恶性肿瘤中检测到人Rgr致癌基因及其截短的转录物，编码多肽的抗体及其使用方法
- Patent Title: Human Rgr oncogene and truncated transcripts thereof detected in T cell malignancies, antibodies to the encoded polypeptides and methods of use
- Patent Title (中): 在T细胞恶性肿瘤中检测到人Rgr致癌基因及其截短的转录物，编码多肽的抗体及其使用方法
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Application No.: US12109809Application Date: 2008-04-25
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Publication No.: US07887808B2Publication Date: 2011-02-15
- Inventor: Angel Pellicer , Peter Leonardi , Giorgio Inghirami
- Applicant: Angel Pellicer , Peter Leonardi , Giorgio Inghirami
- Applicant Address: US NY New York
- Assignee: New York University
- Current Assignee: New York University
- Current Assignee Address: US NY New York
- Agency: Browdy and Neimark, PLLC
- Main IPC: A61K39/395
- IPC: A61K39/395 ; C12P21/08 ; G01N33/567 ; G01N33/48
Abstract:
Naturally-occurring variants of human Rgr oncogene protein, in particular, abnormally truncated variants found in T cell malignancies, as well as the human Rgr protein are encompassed by the present invention. Also included are antibodies thereto and nucleic acid molecules encoding human Rgr protein and naturally-occurring variants thereof. The present invention further provides methods for diagnosing and treating T cell malignancies associated with abnormally truncated transcripts of human rgr oncogene and/or abnormal truncation of human Rgr protein.
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