Invention Grant
US07888115B2 MHC class I peptide epitopes from the human 5T4 tumor-associated antigen
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来自人5T4肿瘤相关抗原的MHC I类肽表位
- Patent Title: MHC class I peptide epitopes from the human 5T4 tumor-associated antigen
- Patent Title (中): 来自人5T4肿瘤相关抗原的MHC I类肽表位
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Application No.: US12501130Application Date: 2009-07-10
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Publication No.: US07888115B2Publication Date: 2011-02-15
- Inventor: Miles William Carroll , Susan Mary Kingsman , Irina Redchenko
- Applicant: Miles William Carroll , Susan Mary Kingsman , Irina Redchenko
- Applicant Address: GB Oxford
- Assignee: Oxford Biomedica (UK) Limited
- Current Assignee: Oxford Biomedica (UK) Limited
- Current Assignee Address: GB Oxford
- Agency: Marshall, Gerstein & Borun LLP
- Priority: GB0203419.7 20020213
- Main IPC: C12N1/00
- IPC: C12N1/00 ; C07H21/02 ; C07H21/04 ; A61K38/00 ; A61K38/08
Abstract:
There is provided an MHC class I peptide epitope from 5T4 antigen. In particular, there is provided a peptide epitope of 5T4 which comprises one of the following: (i) the amino acid sequence shown as SEQ ID No.2; (ii) the minimal epitope from the amino acid sequence shown as SEQ ID No.3; (iii) the minimal epitope from the amino acid sequence shown as SEQ ID No.4. (iv) the minimal epitope from the amino acid sequence shown as SEQ ID No. 5. (v) the minimal epitope from the amino acid sequence shown as SEQ ID No.6. (vi) the minimal epitope from the amino acid sequence shown as SEQ ID No.7. There is also provided a vaccine comprising such a peptide (or precursor thereof) and its use to treat and/or prevent a disease, in particular a cancerous disease.
Public/Granted literature
- US20100086995A1 MHC CLASS I PEPTIDE EPITOPES FROM THE HUMAN 5T4 TUMOR-ASSOCIATED ANTIGEN Public/Granted day:2010-04-08
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