Invention Grant
US07888336B2 Indole compounds bearing aryl or heteroaryl groups having sphingosine 1-phosphate (S1P) receptor biological activity
有权
含有具有鞘氨醇1-磷酸（S1P）受体生物活性的芳基或杂芳基的吲哚化合物
- Patent Title: Indole compounds bearing aryl or heteroaryl groups having sphingosine 1-phosphate (S1P) receptor biological activity
- Patent Title (中): 含有具有鞘氨醇1-磷酸（S1P）受体生物活性的芳基或杂芳基的吲哚化合物
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Application No.: US12679530Application Date: 2008-09-18
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Publication No.: US07888336B2Publication Date: 2011-02-15
- Inventor: Richard L. Beard , Haiqing Yuan , John E. Donello
- Applicant: Richard L. Beard , Haiqing Yuan , John E. Donello
- Applicant Address: US CA Irvine
- Assignee: Allergan, Inc.
- Current Assignee: Allergan, Inc.
- Current Assignee Address: US CA Irvine
- Agent Doina G. Ene; John E. Wurst; Kevin J. Forrestal
- International Application: PCT/US2008/076792 WO 20080918
- International Announcement: WO2009/042485 WO 20090402
- Main IPC: A61K31/661
- IPC: A61K31/661 ; A61K31/4439 ; A61K31/422 ; A61K31/404 ; A61K31/429 ; C07F9/12 ; A61P27/06 ; A61P27/02 ; A61P9/00 ; A61P17/02 ; C07D417/14 ; C07D413/06 ; C07D209/08 ; C07D513/04
Abstract:
The invention provides well-defined aryl and/or heteroaryl substituted indoles that are useful as spingosine-1-phosphate agonists or antagonists. As such, the compounds described herein are useful in treating a wide variety of disorders associated with modulation of sphingosine-1-phosphate receptors.
Public/Granted literature
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