A system and method for ascertaining the identity of an object within an enclosed article. The system includes an acquisition subsystem, a reconstruction subsystem, a computer-aided detection (CAD) subsystem, and an alarm resolution subsystem. The acquisition subsystem communicates view data to the reconstruction subsystem, which reconstructs it into image data and communicates it to the CAD subsystem. The CAD subsystem analyzes the image data to ascertain whether it contains any area of interest. A feedback loop between the reconstruction and CAD subsystems allows for continued, more extensive analysis of the object. Other information, such as risk variables or trace chemical detection information may be communicated to the CAD subsystem to dynamically adjust the computational load of the analysis.