A medical fluid delivery system for the use in the delivery of medical fluids. The medical fluid delivery system may include a pumping system, a disposable medical fluid line set and a valve operating system. The disposable tubing line set may include valves adapted to interface with the valve operating system. The valve operating system may be adapted to operate only selected valves using a single drive means. The pumping system may be operated over a wide range of medical fluid delivery rates by employing a bi-directional drive member and a transmission interfaced with the drive member and a pump.