Methods for designing and performing a treatment operation on a subterranean formation penetrated by a wellbore are provided, in which the treatment operation includes the use of a treatment fluid comprising reactants for a chemical reaction. The methods generally include the step of obtaining wellbore temperature-profile information on the wellbore and obtaining kinetic or thermodynamic data for the chemical reaction, and combining the information to help design the treatment operation. Preferably, the methods include the use of a distributed temperature system (“DTS”) for gaining temperature-profile information for a wellbore.