A microreactor assembly comprising a fluidic interconnect backbone and plurality of fluidic microstructures is provided. The fluidic microstructures are supported by respective portions of the fluidic interconnect backbone, The microreactor assembly comprises a plurality of non-polymeric interconnect seals associated with the interconnect input and output ports. The interconnect input port of the fluidic interconnect backbone is interfaced with the microchannel output port of a first fluidic microstructure at one of the non-polymeric interconnect seals. The interconnect output port of the fluidic interconnect backbone is interfaced with the microchannel input port of a second fluidic microstructure at another of the non-polymeric interconnect seals. The interconnect microchannel is defined entirely by the fluidic interconnect backbone and is configured such that it extends from the non-polymeric interconnect seal at the microchannel output port of the first fluidic microstructure to the non-polymeric interconnect seal at the microchannel input port of the second fluidic microstructure without interruption by additional sealed interfaces.