Invention Grant
US07897148B2 Chimeric and humanized antibodies to α5β1 integrin that modulate angiogenesis
有权
对α5和bgr1整联蛋白的嵌合和人源化抗体调节血管发生
- Patent Title: Chimeric and humanized antibodies to α5β1 integrin that modulate angiogenesis
- Patent Title (中): 对α5和bgr1整联蛋白的嵌合和人源化抗体调节血管发生
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Application No.: US11852147Application Date: 2007-09-07
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Publication No.: US07897148B2Publication Date: 2011-03-01
- Inventor: Vanitha Ramakrishnan , David Powers , Dale E. Johnson , Ursula Jeffry , Vinay Bhaskar
- Applicant: Vanitha Ramakrishnan , David Powers , Dale E. Johnson , Ursula Jeffry , Vinay Bhaskar
- Applicant Address: US CA Redwood City
- Assignee: Abbott Biotherapeutics Corp.
- Current Assignee: Abbott Biotherapeutics Corp.
- Current Assignee Address: US CA Redwood City
- Agency: Sughrue Mion, PLLC
- Main IPC: C07K16/18
- IPC: C07K16/18 ; A61K39/395 ; A61P43/00
Abstract:
The present invention provides chimeric and humanized antibodies that specifically recognize α5β1 integrin, and methods for using the antibodies for reducing or inhibiting angiogenesis in a tissue. Also provided are methods of determining therapeutically acceptable doses of the antibodies and pharmaceutical compositions including the same.
Public/Granted literature
- US20080260732A1 CHIMERIC AND HUMANIZED ANTIBODIES TO ALPHA5BETA1 INTEGRIN THAT MODULATE ANGIOGENESIS Public/Granted day:2008-10-23
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