Invention Grant
US07897155B2 Method for producing yeast expressed HPV types 6 and 16 capsid proteins
有权
酵母表达HPV 6型和16型衣壳蛋白的方法
- Patent Title: Method for producing yeast expressed HPV types 6 and 16 capsid proteins
- Patent Title (中): 酵母表达HPV 6型和16型衣壳蛋白的方法
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Application No.: US12316310Application Date: 2008-12-11
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Publication No.: US07897155B2Publication Date: 2011-03-01
- Inventor: Daniela Tornese Buonamassa , Catherine E. Greer , Cesira L. Galeotti , Giuliano Bensi , Roberto Petracca
- Applicant: Daniela Tornese Buonamassa , Catherine E. Greer , Cesira L. Galeotti , Giuliano Bensi , Roberto Petracca
- Applicant Address: US CA Emeryville
- Assignee: Novartis Vaccines & Diagnostics, Inc.
- Current Assignee: Novartis Vaccines & Diagnostics, Inc.
- Current Assignee Address: US CA Emeryville
- Agent Regina Bautista
- Main IPC: A61K39/12
- IPC: A61K39/12
Abstract:
Mosaic VLPs of viral capsid proteins from different virus types are described, as are methods of making the same. Specifically, a diploid yeast strain that coexpresses the L1 and L2 capsid proteins of both HPV-6 and HPV-16 as mosaic VLPs is described. The mosaic VLPs induced the production of conformational antibodies against both L1 proteins upon administration to mice.
Public/Granted literature
- US20090191238A1 Method for producing yeast expressed HPV types 6 and 16 capsid proteins Public/Granted day:2009-07-30
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