Invention Grant
US07897172B2 Tablets exhibiting reduced drug release variability 有权
显示药物释放变异性降低的片剂

Tablets exhibiting reduced drug release variability
Abstract:
A compressible extended release tablet or tablet layer having a drug release profile that is not strongly dependent on tablet hardness may be prepared by dry blending a pharmaceutically active ingredient with hydroxypropyl methylcellulose, wherein the hydroxypropyl methylcellulose has a bimodal or multimodal number average molecular weight distribution that includes at least one mode over 20,000 Daltons and at least one mode under 10,000 Daltons. An additional advantage of the invention is that the tablet formulations may be prepared without resort to wet granulation.
Public/Granted literature
Information query
Patent Agency Ranking
0/0