Invention Grant
- Patent Title: Methods of screening an agent for an activity in an isolated eye of a teleost
- Patent Title (中): 筛选在硬骨鱼孤立眼中活动的药剂的方法
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Application No.: US12137509Application Date: 2008-06-11
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Publication No.: US07897363B2Publication Date: 2011-03-01
- Inventor: Patricia McGrath , Wen Lin Seng
- Applicant: Patricia McGrath , Wen Lin Seng
- Applicant Address: US MA Cambridge
- Assignee: Phylonix Pharmaceuticals, Inc.
- Current Assignee: Phylonix Pharmaceuticals, Inc.
- Current Assignee Address: US MA Cambridge
- Agency: Hamilton, Brooks, Smith & Reynolds, P.C.
- Main IPC: C12Q1/34
- IPC: C12Q1/34
Abstract:
The present invention provides methods of screening an agent for an activity in an isolated organ, e.g., eye, from a teleost, e.g., zebrafish. Methods of isolating eyes from zebrafish are provided. Methods of screening an agent for an ocular activity in the isolated eye are provided. Methods of screening an agent for an ocular activity in a model of ocular disease or disorder are provided. Methods of screening an agent for an ocular activity in the isolated eye and for screening the agent for cell death and/or toxic activity in the eye or other organ or tissue are provided. The invention further provides high throughput methods of screening agents for an activity in isolated eyes of zebrafish in multi-well plates.
Public/Granted literature
- US20090010849A1 Methods of screening an agent for an activity in an isolated eye of a teleost Public/Granted day:2009-01-08
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